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Journal of Antimicrobial Chemotherapy (2001) 47, 705-707
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Effect of LY333328 against vancomycin-resistant Enterococcus faecium in a rat central venous catheter-associated infection model

Mark E. Ruppa,*, Paul D. Feya and G. Matthew Longob

a Department of Internal Medicine and b Department of Surgery, 984031 University of Nebraska Medical Center, Omaha, NE 68198-4031, USA

A rat central venous catheter (CVC) infection model was used to assess the activity of LY333328 against vancomycin-resistant Enterococcus faecium (VRE). Via the CVC, animals were challenged with 106 cfu of Enterococcus faecium with the VanA phenotype. Eight rats received a single dose of LY333328 and eight rats received saline. Seventy-five per cent of control animals had peripheral bacteraemia and 87.5% had VRE recovered from explanted CVCs at the time they were killed, as compared with 0 and 12.5%, respectively, of the LY333328-treated animals (P < 0.01). All animals in the control group had evidence of metastatic disease compared with none of the treated group (P < 0.01). LY333328 was effective against the strain of VRE tested in this model.

* Corresponding author. Tel: +1-402-559-5276; Fax: +1-402-559-8300; E-mail: merupp{at}unmc.edu


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