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Journal of Antimicrobial Chemotherapy (2001) 47, 701-704
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Efficacy of gatifloxacin alone and in combination with cefepime against penicillin-resistant Streptococcus pneumoniae in a rabbit meningitis model and in vitro

Martin Perriga, Fernando Acostaa, Marianne Cottagnouda, Cynthia M. Gerbera, Martin G. Täuberb and Philippe Cottagnoudc,*

a Department of Internal Medicine, Zieglerspital, 3007 Berne; b Institute of Medical Microbiology, University of Berne; c Department of Internal Medicine, Inselspital, 3010 Berne, Switzerland

Gatifloxacin penetrated well into cerebrospinal fluid (CSF) (49 ± 11%), measured by comparison of AUCCSF/AUCserum, and showed good bactericidal activity (leading to a decrease of 0.75 ± 0.17 log10 cfu/mL/h) in the treatment of experimental meningitis in rabbits caused by a penicillin-resistant pneumococcal strain (MIC 4 mg/L). It was significantly more effective than the standard regimen, ceftriaxone with vancomycin, which led to a decrease of 0.53 ± 0.17 log10 cfu/mL/h. The addition of cefepime to gatifloxacin slightly improved the killing rates (giving a decrease of 0.84 ± 0.14 log10 cfu/mL/h). In vitro, synergy was demonstrated between cefepime and gatifloxacin by the chequerboard method (fractional inhibitory concentration index = 0.5) and by viable counts over 8 h.

* Corresponding author. Tel: +41-31-6322111; Fax: +41-31-6323847; E-mail: pcottagn{at}insel.ch


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