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Journal of Antimicrobial Chemotherapy (2001) 47, 681-684
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Comparative in vitro activity of the new quinolone gemifloxacin (SB-265805) with other fluoroquinolones against respiratory tract pathogens

Fernando García-Garrote, Emilia Cercenado,*, Jesús Martín-Pedroviejo, Oscar Cuevas and Emilio Bouza

Servicio de Microbiología, Hospital General Universitario ‘Gregorio Marañón’, Dr. Esquerdo 46, 28007 Madrid, Spain

The in vitro activity of gemifloxacin (SB-265805) was compared with that of other fluoroquinolones against 302 clinical isolates of Streptococcus pneumoniae, 300 clinical isolates of Haemophilus influenzae and 28 clinical isolates of Moraxella catarrhalis, including multiply resistant strains. Gemifloxacin at 0.12 mg/L inhibited all microorganisms tested. MIC90 values of gemifloxacin, trovafloxacin, grepafloxacin and levofloxacin against all (630) isolates tested were 0.03, 0.12, 0.12 and 1 mg/L, respectively. MIC90 values of the same fluoroquinolones against S. pneumoniae were 0.06, 0.25, 0.12 and 1 mg/L, respectively.

* Corresponding author. Tel: +34-91-586-8459; Fax: +34-91-504-4906; E-mail: ecercenado{at}teleline.es


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