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Journal of Antimicrobial Chemotherapy (2001) 47, 675-680
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

In vitro activity of linezolid and 11 other antimicrobials against 566 clinical isolates and comparison between NCCLS microdilution and Etest methods

F. Tubaua, R. Fernández-Roblasb, J. Liñaresa, R. Martína and F. Sorianob,*

a Service of Microbiology, Hospital de Bellvitge, Barcelona; b Department of Medical Microbiology, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040 Madrid, Spain

The in vitro activity of linezolid and 11 other antimicrobials was determined for 566 clinical isolates of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus spp., Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis, some of them resistant to several antibiotics, using a broth microdilution method and the Etest method. All Gram-positive organisms tested were inhibited by a concentration of <=4 mg/L of linezolid, including methicillin-resistant staphylococci, vancomycin- and ampicillin-resistant enterococci, and penicillin-intermediate and -resistant pneumococci. MICs of linezolid by the Etest method were usually one to two dilution values lower than those obtained by microdilution.

* Corresponding author. Tel: +34-91-544-7387; Fax: +34-91-549-4764; E-mail: fsoriano{at}fjd.es


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