Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (16)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Zarantonelli, L.
Right arrow Articles by Shafer, W. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zarantonelli, L.
Right arrow Articles by Shafer, W. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (2001) 47, 651-654
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Decreased susceptibility to azithromycin and erythromycin mediated by a novel mtr(R) promoter mutation in Neisseria gonorrhoeae

Leticia Zarantonellia,*, Graciela Borthagaraya, Eun Hee Leeb,c, Wendy Vealb,c and William M. Shaferb,c

a National Center for Gonococcal Antimicrobial Susceptibility Surveillance, Department of Microbiology, School of Chemistry, Avda Gral Flores 2124, Montevideo 11800, Uruguay; b Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30332; c Laboratories of Microbial Pathogenesis, Medical Research Service, VA Medical Center (Atlanta), Decatur, GA 30333, USA

During a screen of Neisseria gonorrhoeae clinical isolates obtained in Uruguay for susceptibility to azithromycin, we noticed that approximately 10% of the strains examined displayed decreased susceptibility to azithromycin and erythromycin due to the mtr(CDE)-encoded efflux pump system, but remained susceptible to Triton X-100. We now report that the mtr(R) promoter region of one of these isolates contains a dinucleotide insertion (TT) that mediates this resistance phenotype.

* Corresponding author. Tel: +598-2-924-4209; Fax: +598-2-924-1906; E-mail: lzaranto{at}bilbo.edu.uy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
S. Starnino, P. Stefanelli, and on behalf of the Neisseria gonorrhoeae Italian Stu
Azithromycin-resistant Neisseria gonorrhoeae strains recently isolated in Italy
J. Antimicrob. Chemother., June 1, 2009; 63(6): 1200 - 1204.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
C. E. Rouquette-Loughlin, J. T. Balthazar, and W. M. Shafer
Characterization of the MacA-MacB efflux system in Neisseria gonorrhoeae
J. Antimicrob. Chemother., November 1, 2005; 56(5): 856 - 860.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
K. Poole
Efflux-mediated antimicrobial resistance
J. Antimicrob. Chemother., July 1, 2005; 56(1): 20 - 51.
[Abstract] [Full Text] [PDF]

Home page
 Microbiol. Mol. Biol. Rev.Home page
J. L. Ramos, M. Martinez-Bueno, A. J. Molina-Henares, W. Teran, K. Watanabe, X. Zhang, M. T. Gallegos, R. Brennan, and R. Tobes
The TetR Family of Transcriptional Repressors
Microbiol. Mol. Biol. Rev., June 1, 2005; 69(2): 326 - 356.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
J. P. Folster and W. M. Shafer
Regulation of mtrF Expression in Neisseria gonorrhoeae and Its Role in High-Level Antimicrobial Resistance
J. Bacteriol., June 1, 2005; 187(11): 3713 - 3720.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
S. Cousin Jr., W. L. H. Whittington, and M. C. Roberts
Acquired Macrolide Resistance Genes in Pathogenic Neisseria spp. Isolated between 1940 and 1987
Antimicrob. Agents Chemother., December 1, 2003; 47(12): 3877 - 3880.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
W. L. Veal and W. M. Shafer
Identification of a cell envelope protein (MtrF) involved in hydrophobic antimicrobial resistance in Neisseria gonorrhoeae
J. Antimicrob. Chemother., January 1, 2003; 51(1): 27 - 37.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
L. Arreaza, F. Vazquez, B. Alcala, L. Otero, C. Salcedo, and J. A. Vazquez
Emergence of gonococcal strains with resistance to azithromycin in Spain
J. Antimicrob. Chemother., January 1, 2003; 51(1): 190 - 191.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.