Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Endo, H.
Right arrow Articles by Higuchi, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Endo, H.
Right arrow Articles by Higuchi, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (2001) 47, 405-410
© 2001 The British Society for Antimicrobial Chemotherapy

Effects of lansoprazole, clarithromycin and pH gradient on uptake of [14C]amoxycillin into rat gastric tissue

H. Endo,*, H. Yoshida, N. Ohmi and S. Higuchi

Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd, 403, Yoshino-cho 1-chome, Omiya-shi, Saitama 330-8530, Japan

The effect of lansoprazole and clarithromycin on the uptake of [14C]amoxycillin into rat gastric tissue was investigated. After oral administration of [14C]amoxycillin, the levels of radioactivity in gastrointestinal tissue were two to 15 times higher than those in plasma. The level of radioactivity in glandular stomach was significantly higher when lansoprazole and [14C]amoxycillin were administered together. After intravenous administration of [14C]amoxycillin, there was less radioactivity in gastric tissue than after oral administration, and co-administration of lansoprazole and clarithromycin had no obvious effect. The gastric emptying rate of [14C]amoxycillin was not apparently affected by the co-administration of lansoprazole and clarithromycin. In vitro uptake of [14C]amoxycillin into gastric tissue depended on the pH, with uptake at pH 7.4 being four times greater than that at pH 4.0. The apparent synergic effects of lansoprazole are due to enhanced penetration of amoxycillin in gastric mucus and tissue by increasing intragastric pH and play an important role in the eradication of H. pylori.

* Corresponding author. Tel: +81-48-663-1111; Fax: +81-48-652-7254; E-mail: S14952{at}ccm.taisho.co.jp


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
D. Mainz, K. Borner, P. Koeppe, J. Kotwas, and H. Lode
Pharmacokinetics of lansoprazole, amoxicillin and clarithromycin after simultaneous and single administration
J. Antimicrob. Chemother., November 1, 2002; 50(5): 699 - 706.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
H. Endo, H. Yoshida, Y. Kohno, and T. Suga
Effects of Clarithromycin and Amoxicillin on Gastric Emptying in Rats
Antimicrob. Agents Chemother., October 1, 2002; 46(10): 3331 - 3333.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
H. Endo, H. Yoshida, N. Ohmi, K. Ohta, and S. Higuchi
Localization of [14C]amoxicillin in rat gastric tissue when administered with lansoprazole and clarithromycin
J. Antimicrob. Chemother., December 1, 2001; 48(6): 923 - 926.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.