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Journal of Antimicrobial Chemotherapy (2001) 47, 203-206
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Synergic activity of D-cycloserine and ß-chloro-D-alanine against Mycobacterium tuberculosis

Suzana David,*

Unit of Mycobacteriology and Centro de Malária e outras Doenças Tropicais /IHMT/Universidade Nova de Lisboa, Rua da Junqueira 96, 1349-008 Lisbon, Portugal

D-Cycloserine (DCS) is a peptidoglycan inhibitor. Although very effective against Mycobacterium tuberculosis, it is seldom employed in the management of this infection due to its high toxicity. ß-Chloro-D-alanine (another peptidoglycan inhibitor) reduces the MIC of DCS from 50 to 2.5 mg/L at a concentration significantly below its MIC for this organism. A reduction in bacterial viability and significant growth inhibition (as quantified by the X/Y quotient for the Bactec radiometric procedure) were observed with subinhibitory concentrations of both drugs. It is suggested that this powerful synergic effect should be the object of in vivo and eventually clinical trials.

* Tel/Fax: +351-1-362-24-58; E-mail: suzanadavid{at}ihmt.unl.pt


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This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
Z. Feng and R. G. Barletta
Roles of Mycobacterium smegmatisD-Alanine:D-Alanine Ligase and D-Alanine Racemase in the Mechanisms of Action of and Resistance to the Peptidoglycan Inhibitor D-Cycloserine
Antimicrob. Agents Chemother., January 1, 2003; 47(1): 283 - 291.
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