Journal of Antimicrobial Chemotherapy (2001) 47, 87-91
© 2001 The British Society for Antimicrobial Chemotherapy
Brief report |
High rates of resistance to cephalosporins among viridans-group streptococci causing bacteraemia in neutropenic cancer patients
a Services of Infectious Diseases, b Microbiology and c Clinical Haematology, Hospital de Bellvitge, Institut Català d'Oncologia, Ciutat Sanitària i Universitària de Bellvitge, University of Barcelona, Spain
The prevalence of resistance to cephalosporins among viridans-group streptococci causing 88 (18%) cases among 485 bacteraemias in neutropenic cancer patients was studied. Rates of resistance to ceftriaxone, ceftazidime, cefpirome and cefepime were 22, 53, 14 and 34%, respectively. Previous administration of ß-lactam therapy was the only factor significantly associated with bacteraemia due to cephalosporin-resistant strains; only 11 (16%) of 68 patients infected with cephalosporin-susceptible bacteria had received these antibiotics compared with 10 (50%) of 20 patients infected with cephalosporin-resistant bacteria (P = 0.0052).
* Correspondence address. Feixa Llarga s/n, 08907 l'Hospitalet, Barcelona, Spain. Tel: +34-93-3357011 (ext. 2487); Fax: +34-93-2607637; E-mail: jcarratala{at}csub.scs.es
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