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Journal of Antimicrobial Chemotherapy (2001) 47, 109-112
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Persistent viral load in patients on HAART is associated with a higher level of activation-induced apoptosis of CD4+ T cells

Pierre-Marie Rogera,*, Jean-Philippe Breittmayerb, Jacqueline Cottalordac, Michel Ticchionib, Véronique Mondaina, Pierre Dellamonicaa and Alain Bernardb

a Service des Maladies Infectieuses et Tropicales, b Laboratoire d'Immunologie – INSERM U343, Hôpital de l'Archet and c Laboratoire de Virologie, Hôpital Pasteur, Nice, France

Apoptosis is one of the mechanisms involved in the persistent CD4+ T cell lymphopenia occurring in human immunodeficiency virus (HIV)-infected patients treated with highly active antiretroviral therapy (HAART). The aim of this study was to look at the relationship between the level of T cell apoptosis in patients on HAART and their HIV viral load measurement. Forty-five patients receiving HAART for a median time of 5 months were included: 13 had an undetectable viral load and 32 had a viral load >=200 copies/mL. No relationship was observed between the level of spontaneous T cell apoptosis and the viral load measurement. Patients with a viral load >=200 copies/mL exhibited a significantly higher level of CD4-induced apoptosis of CD4+ T cells, compared with patients with undetectable viraemia (38 versus 15%, respectively, P = 0.03). Activation-induced apoptosis may be involved in the paucity of the immune reconstitution observed in HIV-infected patients treated with HAART.

* Correspondence address. Service des Maladies Infectieuses et Tropicales, Hôpital de l'Archet, Route St Antoine de Ginestière, BP79, 06202, Nice, France. Tel: +33-4-92-03-54-52; Fax: +33-4-93-96-54-54.


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P.-M. Roger, J. Durant, M. Ticchioni, P. Halfon, J.-P. Breittmayer, C. Brignone, S. Chaillou, B. Dunais, P. Dellamonica, A. Bernard, et al.
Apoptosis and proliferation kinetics of T cells in patients having experienced antiretroviral treatment interruptions
J. Antimicrob. Chemother., August 1, 2003; 52(2): 269 - 275.
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