Journal of Antimicrobial Chemotherapy (2000) 46, 11-15
© 2000 The British Society for Antimicrobial Chemotherapy
Comparative in vitro potency of gemifloxacin against European respiratory tract pathogens isolated in the Alexander Project
Institute of Microbiology, University of Genoa Medical School, Largo Rosanna Benzi 10, 16132 Genoa, Italy
European isolates collected in 1998 for the Alexander Project were tested for their susceptibility to ciprofloxacin, ofloxacin and a novel fluoroquinolone, gemifloxacin, which has a spectrum of activity including common and atypical respiratory pathogens. MIC90s of gemifloxacin for Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis were 0.03, 0.06 and 0.015 mg/L, respectively. On the basis of MIC90s, gemifloxacin was the most potent antimicrobial tested against S. pneumoniae and M. catarrhalis. Against H. influenzae, gemifloxacin was one tube dilution more potent than ofloxacin and one tube dilution less potent than ciprofloxacin. As resistance to currently available antimicrobial agents increases, gemifloxacin offers potential as a promising new agent for the treatment of respiratory tract infection.
* Corresponding author. Tel: +39-010-3537646 or 502136; Fax: +39-010-504837; E-mail: schitogc{at}aleph.it
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Doyle, E.-A. Feuerbaum, K. R. Fox, J. Hinds, D. E. Thurston, and P. W. Taylor Response of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimer J. Antimicrob. Chemother., November 1, 2009; 64(5): 949 - 959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nuryastuti, H. C. van der Mei, H. J. Busscher, S. Iravati, A. T. Aman, and B. P. Krom Effect of Cinnamon Oil on icaA Expression and Biofilm Formation by Staphylococcus epidermidis Appl. Envir. Microbiol., November 1, 2009; 75(21): 6850 - 6855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Stickler and G. L. Jones Reduced Susceptibility of Proteus mirabilis to Triclosan Antimicrob. Agents Chemother., March 1, 2008; 52(3): 991 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bayston, W. Ashraf, and T. Smith Triclosan resistance in methicillin-resistant Staphylococcus aureus expressed as small colony variants: a novel mode of evasion of susceptibility to antiseptics J. Antimicrob. Chemother., May 1, 2007; 59(5): 848 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. F. Seaman, D. Ochs, and M. J. Day Small-colony variants: a novel mechanism for triclosan resistance in methicillin-resistant Staphylococcus aureus J. Antimicrob. Chemother., January 1, 2007; 59(1): 43 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Kampf and A. Kramer Epidemiologic Background of Hand Hygiene and Evaluation of the Most Important Agents for Scrubs and Rubs Clin. Microbiol. Rev., October 1, 2004; 17(4): 863 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Aiello, B. Marshall, S. B. Levy, P. Della-Latta, and E. Larson Relationship between Triclosan and Susceptibilities of Bacteria Isolated from Hands in the Community Antimicrob. Agents Chemother., August 1, 2004; 48(8): 2973 - 2979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. K Yoo, D. M Triller, C.-S. Yong, and T. P Lodise Gemifloxacin: A New Fluoroquinolone Approved for Treatment of Respiratory Infections Ann. Pharmacother., July 1, 2004; 38(7): 1226 - 1235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Russell Whither triclosan? J. Antimicrob. Chemother., May 1, 2004; 53(5): 693 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Schmid and N. Kaplan Reduced Triclosan Susceptibility in Methicillin-Resistant Staphylococcus epidermidis Antimicrob. Agents Chemother., April 1, 2004; 48(4): 1397 - 1399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Braoudaki and A. C. Hilton Adaptive Resistance to Biocides in Salmonella enterica and Escherichia coli O157 and Cross-Resistance to Antimicrobial Agents J. Clin. Microbiol., January 1, 2004; 42(1): 73 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. McBain, R. G. Bartolo, C. E. Catrenich, D. Charbonneau, R. G. Ledder, and P. Gilbert Effects of Triclosan-Containing Rinse on the Dynamics and Antimicrobial Susceptibility of In Vitro Plaque Ecosystems Antimicrob. Agents Chemother., November 1, 2003; 47(11): 3531 - 3538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Russell Similarities and differences in the responses of microorganisms to biocides J. Antimicrob. Chemother., November 1, 2003; 52(5): 750 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Smith, D. Morrison, D. Robertson, M. K. Tang, and Z. Al-Doori Efficacy of oral hygiene products against MRSA and MSSA isolates J. Antimicrob. Chemother., October 1, 2003; 52(4): 738 - 739. [Full Text] [PDF]
|
|
|
|
|
|
P. Gilbert and A. J. McBain Potential Impact of Increased Use of Biocides in Consumer Products on Prevalence of Antibiotic Resistance Clin. Microbiol. Rev., April 1, 2003; 16(2): 189 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Al-Doori, D. Morrison, G. Edwards, and C. Gemmell Susceptibility of MRSA to triclosan J. Antimicrob. Chemother., January 1, 2003; 51(1): 185 - 186. [Full Text] [PDF]
|
|
|
|
|
|
P. Gilbert, A. J. McBain, and S. F. Bloomfield Biocide abuse and antimicrobial resistance: being clear about the issues J. Antimicrob. Chemother., July 1, 2002; 50(1): 137 - 139. [Full Text] [PDF]
|
|