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Journal of Antimicrobial Chemotherapy (2000) 46, 981-985
© 2000 The British Society for Antimicrobial Chemotherapy

Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model

Philippe Cottagnouda,*, Cynthia M. Gerberb, F. Acostab, Marianne Cottagnoudb, Klaus Neftelb and Martin G. Täuberc

a Department of Internal Medicine, Inselspital, Freiburgstrasse, 3010 Berne; b Department of Internal Medicine, Zieglerspital, Berne; c Institute for Medical Microbiology, University of Berne, Berne, Switzerland

Linezolid, a new oxazolidinone antibiotic, showed good penetration (38 ± 4%) into the meninges of rabbits with levels in the CSF ranging from 9.5 to 1.8 mg/L after two iv injections (20 mg/kg). Linezolid was clearly less effective than ceftriaxone against a penicillin-sensitive pneumococcal strain. Against a penicillin-resistant strain, linezolid had slightly inferior killing rates compared with the standard regimen (ceftriaxone combined with vancomycin). In vitro, linezolid was marginally bactericidal at concentrations above the MIC (5 x and 10 x MIC).

* Corresponding author. Tel: +41-316-32-2111; Fax: +41-316-32-3847; E-mail: pcottagn{at}insel.ch


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