Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (26)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Murugasu-Oei, B.
Right arrow Articles by Dick, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murugasu-Oei, B.
Right arrow Articles by Dick, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (2000) 46, 917-919
© 2000 The British Society for Antimicrobial Chemotherapy

Bactericidal activity of nitrofurans against growing and dormant Mycobacterium bovis BCG

Bernadette Murugasu-Oei and Thomas Dick*

Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore

Depletion of oxygen triggers the shift-down of Mycobacterium bovis BCG to a state of dormancy. Bacilli in their dormant state are resistant to standard anti-mycobacterials. The nitroimidazole metronidazole was the first compound identified to show bactericidal activity against dormant tubercle bacilli. In contrast to metronidazole's selective toxicity for dormant bacilli, we report here that the nitrofurans nitrofurantoin, furaltadone and nitrofurazone showed bactericidal activity against dormant and growing bacteria. Importantly, the bactericidal effect of nitrofurans on dormant bacilli was 35- to 250-fold higher compared with metronidazole.

* Corresponding author. Tel: +65-874-8606; Fax: +65-779-1117; E-mail: mcbtd{at}imcb.nus.edu.sg


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
J. G. Hurdle, R. B. Lee, N. R. Budha, E. I. Carson, J. Qi, M. S. Scherman, S. H. Cho, M. R. McNeil, A. J. Lenaerts, S. G. Franzblau, et al.
A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents
J. Antimicrob. Chemother., November 1, 2008; 62(5): 1037 - 1045.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
O. Y. Saliu, C. Crismale, S. K. Schwander, and R. S. Wallis
Bactericidal activity of OPC-67683 against drug-tolerant Mycobacterium tuberculosis
J. Antimicrob. Chemother., November 1, 2007; 60(5): 994 - 998.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
N. K. Taneja and J. S. Tyagi
Resazurin reduction assays for screening of anti-tubercular compounds against dormant and actively growing Mycobacterium tuberculosis, Mycobacterium bovis BCG and Mycobacterium smegmatis
J. Antimicrob. Chemother., August 1, 2007; 60(2): 288 - 293.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. J. Lenaerts, V. Gruppo, K. S. Marietta, C. M. Johnson, D. K. Driscoll, N. M. Tompkins, J. D. Rose, R. C. Reynolds, and I. M. Orme
Preclinical Testing of the Nitroimidazopyran PA-824 for Activity against Mycobacterium tuberculosis in a Series of In Vitro and In Vivo Models
Antimicrob. Agents Chemother., June 1, 2005; 49(6): 2294 - 2301.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
D. J. V. Beste, J. Peters, T. Hooper, C. Avignone-Rossa, M. E. Bushell, and J. McFadden
Compiling a Molecular Inventory for Mycobacterium bovis BCG at Two Growth Rates: Evidence for Growth Rate-Mediated Regulation of Ribosome Biosynthesis and Lipid Metabolism
J. Bacteriol., March 1, 2005; 187(5): 1677 - 1684.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
G. Di Perri and S. Bonora
Which agents should we use for the treatment of multidrug-resistant Mycobacterium tuberculosis?
J. Antimicrob. Chemother., September 1, 2004; 54(3): 593 - 602.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
C. Boon and T. Dick
Mycobacterium bovis BCG Response Regulator Essential for Hypoxic Dormancy
J. Bacteriol., December 15, 2002; 184(24): 6760 - 6767.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
H. L. Peh, A. Toh, B. Murugasu-Oei, and T. Dick
In Vitro Activities of Mitomycin C against Growing and Hypoxic Dormant Tubercle Bacilli
Antimicrob. Agents Chemother., August 1, 2001; 45(8): 2403 - 2404.
[Full Text] [PDF]

Home page
 J. Bacteriol.Home page
C. Boon, R. Li, R. Qi, and T. Dick
Proteins of Mycobacterium bovis BCG Induced in the Wayne Dormancy Model
J. Bacteriol., April 15, 2001; 183(8): 2672 - 2676.
[Abstract] [Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.