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Journal of Antimicrobial Chemotherapy (2000) 46, 831-834
© 2000 The British Society for Antimicrobial Chemotherapy

Brief report

Effect of a novel mucoadhesive polysaccharide obtained from tamarind seeds on the intraocular penetration of gentamicin and ofloxacin in rabbits

E. Ghelardia,*, A. Tavantia, F. Celandronia, A. Lupettia, C. Blandizzib, E. Boldrinic, M. Campaa and S. Senesia

a Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia and b Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Università degli Studi di Pisa, Pisa, Italy; c Farmigea S.p.A., Pisa, Italy

This report describes the efficacy of a novel mucoadhesive polymer, the tamarind seed polysaccharide, as a delivery system for the ocular administration of hydrophilic and hydrophobic antibiotics. Healthy rabbits were subjected to repeated ocular instillations with either conventional gentamicin or ofloxacin or these agents viscosified with the tamarind seed polysaccharide. Administration of viscosified preparations produced antibiotic concentrations both in the aqueous humour and cornea that were significantly higher than those achieved with the drugs alone. The increased drug absorption and the prolonged drug elimination phase obtained with the viscosified formulations indicate the usefulness of the tamarind seed polysaccharide as an ophthalmic delivery system for topical administration of antibiotics.

* Correspondence address. Via S. Zeno 35–39, 56127 Pisa, Italy. Tel: +39-050-836569; Fax: +39-050-836570; E-mail: ghelardi{at}biomed.unipi.it


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E. Ghelardi, A. Tavanti, P. Davini, F. Celandroni, S. Salvetti, E. Parisio, E. Boldrini, S. Senesi, and M. Campa
A Mucoadhesive Polymer Extracted from Tamarind Seed Improves the Intraocular Penetration and Efficacy of Rufloxacin in Topical Treatment of Experimental Bacterial Keratitis
Antimicrob. Agents Chemother., September 1, 2004; 48(9): 3396 - 3401.
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