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Journal of Antimicrobial Chemotherapy (2000) 46, 819-821
© 2000 The British Society for Antimicrobial Chemotherapy

Brief report

Metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France

V. Leméea,*, I. Zahariaa, G. Nevezb, M. Rabodonirinac, P. Brasseura, J. J. Balletd and L. Favenneca

a Laboratoire de Parasitologie Expérimentale, CHU Charles-Nicolle, 76031 Rouen Cedex; b Laboratoire de Parasitologie, CHU Amiens-Sûd, 80054 Amiens Cedex 1; c Laboratoire de Parasitologie, Hôpital Edouard-Herriot, 8 avenue Rockfeller, 69373 Lyon; d Laboratoire d'Immunologie et d'Immunopathologie, CHU Clémenceau, 14033 Caen, France

The metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France was determined using a neonatal mouse model and compared with the outcome in patients after standard metronidazole therapy (0.75 g/day for 5 days). All isolates found to be clinically resistant to metronidazole (4/11) exhibited an ID50 > 120 mg/kg in the mouse model. This therefore appears to be a suitable animal model in which to explore drug failures in human giardiasis.

* Corresponding author. Tel/Fax: +33-2-35-14-85-81; E-mail: llemee1234{at}aol.com


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