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Journal of Antimicrobial Chemotherapy (2000) 46, 621-624
© 2000 The British Society for Antimicrobial Chemotherapy

Brief report

Antimicrobial resistance in Streptococcus pyogenes isolates in Berlin

Mardjan Arvanda,*, Marlies Hoeckb, Helmut Hahna and Jutta Wagnera

a Institut für Infektionsmedizin, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 27, 12203 Berlin; b DRK-Klinik Mark-Brandenburg, Drontheimer Strasse 39, 13359 Berlin, Germany

A total of 212 clinical Streptococcus pyogenes isolates were tested for susceptibility to various antibiotics by agar dilution. The overall frequency of erythromycin resistance was 12.7%, being higher in isolates from children (18.9%) than in those from adult patients (10.7%). Similar results were found for clarithromycin, while 2.8% of the isolates were resistant to ciprofloxacin. All strains were susceptible to penicillin and cefotaxime. Of the erythromycin-resistant isolates subjected to the double-disc diffusion test for erythromycin and clindamycin, 35% expressed constitutive and 55% inducible resistance to clindamycin. Ten per cent were susceptible to clindamycin (M-phenotype). Thus, a high rate of macrolide resistance in S. pyogenes has emerged in Berlin.

*Corresponding author. Tel: +49-30-8445-3602; Fax: +49-30-8445-3830; E-mail: arvand{at}zedat.fu-berlin.de


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