Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (9)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Girmenia, C.
Right arrow Articles by Martino, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Girmenia, C.
Right arrow Articles by Martino, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (2000) 46, 479-484
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

In vitro activity of fluconazole and voriconazole against isolates of Candida albicans from patients with haematological malignancies

Corrado Girmeniaa,*, Clelia Tuccinardia, Stefania Santillia, Francesca Mondellob, Monica Monacoa, Antonio Cassoneb and Pietro Martinoa

a Dipartimento di Biotecnologie Cellulari ed Ematologia, University ‘La Sapienza’, Via Benevento 6, 00161 Rome; b Laboratorio di Batteriologia e Micologia Medica, Istituto Superiore di Sanita, Rome, Italy

We evaluated the activity of fluconazole and voriconazole against 83 Candida albicans isolates from patients with haematological malignancies, comparing the NCCLS microdilution method (M27-A) with a modified method with RPMI–2% glucose and MIC endpoint at 50% inhibition. Both drugs were highly active regardless of the year, the site of isolation of the strain and the test method employed. In several strains isolated during the last few years, trailing growth leading to difficulty in interpretation of the endpoint of the test has been observed for both drugs by the NCCLS method, but not by the modified method. In our experience, azole resistance of C. albicans is still not a clinical problem, however, the emerging phenomenon of the ‘trailing effect’ by the NCCLS method, even though resolvable by technical modifications, seems at least to indicate a reduction in the inhibitory activity of the azoles.

* Corresponding author. Tel: +39-06-857951; Fax: +39-06-44241984; E-mail: girmenia{at}bce.med.uniroma1.it


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
F. Mondello, F. De Bernardis, A. Girolamo, G. Salvatore, and A. Cassone
In vitro and in vivo activity of tea tree oil against azole-susceptible and -resistant human pathogenic yeasts
J. Antimicrob. Chemother., May 1, 2003; 51(5): 1223 - 1229.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
E. Chryssanthou and M. Cuenca-Estrella
Comparison of the Antifungal Susceptibility Testing Subcommittee of the European Committee on Antibiotic Susceptibility Testing Proposed Standard and the E-Test with the NCCLS Broth Microdilution Method for Voriconazole and Caspofungin Susceptibility Testing of Yeast Species
J. Clin. Microbiol., October 1, 2002; 40(10): 3841 - 3844.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.