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Journal of Antimicrobial Chemotherapy (2000) 46, 475-477
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Susceptibility of fluconazole-resistant clinical isolates of Candida spp. to echinocandin LY303366, itraconazole and amphotericin B

Manuel Cuenca-Estrella*, Emilia Mellado, Teresa M. Díaz-Guerra, Araceli Monzón and Juan L. Rodríguez-Tudela

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra Majadahonda-Pozuelo Km. 2, 28220 Majadahonda (Madrid), Spain

The in vitro activity of LY303366 was compared with those of itraconazole and amphotericin B against 156 fluconazole-resistant (MIC >= 16 mg/L) clinical isolates of Candida spp. An adaptation of the NCCLS reference method was employed for determination of MICs. LY303366 was more potent than either itraconazole or amphotericin B against Candida albicans, Candida glabrata, Candida krusei and Candida tropicalis, even against isolates with itraconazole MICs >= 1 mg/L. LY303366 was less potent in vitro against Candida parapsilosis and Candida guilliermondii isolates. LY303366 has promising antifungal activity and warrants further investigation.

* Corresponding author. Tel: +34-91-5097961; Fax: +34-91-5097966; E-mail: micologia{at}isciii.es


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