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Journal of Antimicrobial Chemotherapy (2000) 46, 461-464
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

In vitro activities of parenteral ß-lactam antimicrobials against TEM-10-, TEM-26- and SHV-5-derived extended-spectrum ß-lactamases expressed in an isogenic Escherichia coli host

Jill A. Rebucka, Keith M. Olsena,*, Paul D. Feyb, Kimberly L. Bergmana and Mark E. Ruppb

a Department of Pharmacy Practice and b Department of Internal Medicine, University of Nebraska Medical Center, 986045 Nebraska Medical Center, Omaha, NE 68198-6045, USA

The in vitro activities were determined and time–kill studies of cefepime, imipenem–cilastatin, meropenem and piperacillin–tazobactam were performed against SHVand TEM-derived extended-spectrum ß-lactamases (ESBLs). Sequence-confirmed SHV-5, TEM-10 and TEM-26 ß-lactamases were transferred into Escherichia coli C600N by conjugation. Imipenem and meropenem were more active (MIC range 0.0625–0.25 mg/L) than cefepime (MIC range 2–8 mg/L) and piperacillin–tazobactam (MIC range 8–32 mg/L). Regrowth of strains expressing TEM-10 and TEM-26 was noted at all cefepime and piperacillin–tazobactam concentrations studied. Imipenem–cilastatin and meropenem demonstrated rapid, sustained bactericidal activity uninfluenced by the type of ESBL expressed.

* Corresponding author. Tel: +1-402-559-9016; Fax: +1-402-559-5673; E-mail: kolsen{at}unmc.edu


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