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Journal of Antimicrobial Chemotherapy (2000) 46, 315-317
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Plasma, urine and skin pharmacokinetics of cefepime in burns patients

Emmanuelle Sampola, Alexis Jacqueta, Marc Viggianob, Victor Berninib, Jean-Claude Manellib, Bruno Lacarellea,* and Alain Durandb

a Laboratory of Pharmacokinetics, Hôpital de la Timone and Université de la Méditerranée, and b Department of Anesthesiology and Regional Burn Center, Hôpital de la Conception, Marseille, France

We studied the pharmacokinetics of cefepime (2 g bd) in six burns patients. Blood, urine and skin samples were collected to measure cefepime concentrations. A two-compartment model was fitted to the data. At day 1, t1/2ß was 2.45 ± 0.56 h, Vss 0.36 ± 0.1 L/kg, total clearance 152 ± 25.2 mL/min, and AUC 217 ± 34 mg•h/L. There was no statistical difference between day 1 and day 3 for any of the pharmacokinetic parameters. We demonstrated good penetration of cefepime in skin. These results show that it is not necessary to change the standard dosage of cefepime in burns patients.

* Correspondence address. Laboratoire de Pharmacocinétique, Hôpital de la Timone, rue Saint-Pierre, 13385 Marseille Cedex 5, France. Tel: +33-4-91-83-56-08; Fax: +33-4-91-26-89-94; E-mail: bruno.lacarelle{at}pharmacie.univ-mrs.fr


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