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Journal of Antimicrobial Chemotherapy (2000) 46, 311-314
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with a biodegradable system of lactic acid polymer releasing pefloxacin

Kyriaki Kanellakopouloua, Nearchos Galanakisb, Evangelos J. Giamarellos-Bourboulisc, Christos Rifiotisd, Konstantinos Papakostasd, Andreas Andreopoulose, Eleftherios Dounisd, Panagiotis Karagianakosf and Helen Giamarelloua,*

a 4th Department of Internal Medicine, Athens Medical School; b 2nd Department of Internal Medicine, Nikaia General Hospital; c 1st Department of Propaedeutic Medicine, Athens Medical School; d Department of Orthopaedics, Athens Laiko General Hospital; e Department of Chemical Engineering, National Polytechnic School, Athens; f Department of Experimental Surgery, Athens Medical School, Athens, Greece

A novel biodegradable system of D-,L-dilactide delivering pefloxacin was implanted in 104 rabbits with experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA), 26 serving as controls. Animals were killed on each third day and viable bacterial counts and levels of pefloxacin in bone tissue were determined. A 99.9% decrease in viable count of bacteria was achieved by day 12 and complete bacterial eradication on day 33. Pefloxacin was released gradually, reaching its peak on day 15 at levels 100 times the MIC of pefloxacin for MRSA. The biodegradable system described may have a future role in the therapeutic approach to osteomyelitis.

* Correspondence address. 4th Department of Internal Medicine, Sismanoglio General Hospital, 15126 Maroussi Attikis, Greece. Tel: +301-80-39-542/+301-80-33-817; Fax: +301-80-39-543.


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