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Journal of Antimicrobial Chemotherapy (2000) 46, 287-290
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

In vitro antibiotic susceptibility of Francisella tularensis isolated from humans and animals

I. Ikäheimoa,*, H. Syrjäläb, J. Karhukorpic, R. Schildtd and M. Koskelaa

a Clinical Microbiology Laboratory and b Department of Infection Control, Oulu University Hospital; and c Department of Medical Microbiology, Universityof Oulu, Oulu; d The National Veterinary and Food Research Institute, Helsinki, Finland

The in vitro susceptibility of 38 strains of Francisella tularensis (biovar F. tularensis palaearctica) was determined using Etests on cysteine heart agar plates with 2% haemoglobin. All strains were susceptible to the antibiotics traditionally used to treat tularaemia, such as streptomycin (MIC90 4.0 mg/L), tetracycline (MIC90 0.38 mg/L) and chloramphenicol (MIC90 0.38 mg/L), and to aminoglycosides, such as tobramycin (MIC90 1.5 mg/L) and gentamicin (MIC90 1.0 mg/L). The quinolones examined had low MIC90s: ciprofloxacin, 0.016 mg/L; levofloxacin, 0.016 mg/L; grepafloxacin, 0.047 mg/L; and trovafloxacin, 0.032 mg/L. In contrast, all the strains were resistant to ß-lactams and azithromycin. Quinolones thus seem to be promising drugs for the treatment of tularaemia.

* Correspondence address. Clinical Microbiology Laboratory, Oulu University Hospital, PO Box 22, 90221 Oulu, Finland. Tel: +358-8-3154005; Fax: +358-8-3154020; E-mail: irma.ikaheimo{at}ppshp.fi


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