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Journal of Antimicrobial Chemotherapy (2000) 46, 91-94
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Effect of grepafloxacin on cytokine production in vitro

Yukihisa Ono*, Yasukazu Ohmoto, Kenji Ono, Yasuyo Sakata and Kaori Murata

Cellular Technology Institute, Otsuka Pharmaceutical Co. Ltd, 463-10 Kagasuno, Kawauchi-cho, Tokushima City, Japan

The effect of a new quinolone antibacterial agent, grepafloxacin, on the production of cytokines was investigated using lipopolysaccharide-stimulated human peripheral blood cells. Grepafloxacin 1–30 mg/L inhibited the production of interleukin 1{alpha} (IL-1{alpha}) and IL-1ß, and the expression of IL-1{alpha}, IL-1ß, tumour necrosis factor {alpha} (TNF{alpha}), IL-6 and IL-8 mRNA. These results suggest that the inhibitory effect of grepafloxacin is exerted, in part, at the gene transcription level.

* Corresponding author. Tel: +81-665-2126; Fax: +81-665-6976; E-mail: y_ono{at}research.otsuka.co.jp


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