Journal of Antimicrobial Chemotherapy (2000) 46, 57-60
© 2000 The British Society for Antimicrobial Chemotherapy
Efficacy of nitazoxanide, tizoxanide and tizoxanide glucuronide against Cryptosporidium parvum development in sporozoite-infected HCT-8 enterocytic cells
a Laboratoire d'Immunologie et Immunopathologie, UPRES-EA 2128, CHU, 14033 Caen; b Laboratoire de Parasitologie Expérimentale, UPRES-JE 2008, CHU, 76000 Rouen, France
The effects of nitazoxanide and its metabolites, tizoxanide and tizoxanide glucuronide, on the development of the asexual and sexual stages of Cryptosporidium parvum in differentiated human enterocytic HCT-8 cells were evaluated in a quantitative alkaline phosphatase immunoassay. Nitazoxanide, tizoxanide and tizoxanide glucuronide were inhibitory for up to 46 h when added after sporozoite invasion (MIC50 1.2, 22.6 and 2.2 mg/L, respectively). Tizoxanide had only limited activity, but nitazoxanide and tizoxanide glucuronide strongly inhibited asexual and sexual stages, respectively.
* Correspondence address. Service d'Immunologie et Immunopathologie, CHU Clemenceau, 14033 Caen Cedex, France. Tel: +33-2-31272551; Fax: +33-2-31272550; E-mail: ballet-jj{at}chu-caen.fr
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