Journal of Antimicrobial Chemotherapy (2000) 46, 45-50
© 2000 The British Society for Antimicrobial Chemotherapy
The antimicrobial efficacy of a new central venous catheter with long-term broad-spectrum activity
a Institute for Scientific Evaluation of Naturopathy, University of Cologne, Robert-Koch-strasse 10, 50931 Cologne; b Institute of Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19–21, 50935 Cologne, Germany
Indwelling vascular catheters are a major cause of nosocomial sepsis. Prevention of colonization of polymeric surfaces by continuous release of bactericidal, highly biocompatible antimicrobials incorporated into polymers has been investigated as a promising new approach. An antimicrobial polyurethane catheter was investigated by HPLC and various antimicrobial assays. Controlled drug delivery governed by the physico-chemical mass transfer from the polyurethane bulk provided long-term release of the antimicrobial substances from the material to the outer surface and catheter lumen. The in vitro activity of catheters coated with miconazole and rifampicin against 158 clinical isolates of catheter-associated infections was evaluated. Incubated in physiological NaCl at 37°C, the half-life of inhibitory activity of catheters coated with miconazole or rifampicin exceeded 3 weeks. In static and dynamic adhesion assays, coated catheters were able to prevent colonization with Staphylococcus aureus, Staphylococcus epidermidis and enterococci. To produce catheters resistant to infection, a potent antimicrobial efficacy combined with an excellent biocompatibility over time is needed. The long lasting efficacy of the antimicrobial polyurethane alloy as well as the increased antifungal activity of miconazole combined with rifampicin may be regarded as a promising improvement for long-term central venous access.
* Corresponding author. Tel/Fax: +49-2204-609545.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. A. Helmick, A. E. Fletcher, A. M. Gardner, C. R. Gessner, A. N. Hvitved, M. C. Gustin, and P. R. Gardner Imidazole Antibiotics Inhibit the Nitric Oxide Dioxygenase Function of Microbial Flavohemoglobin Antimicrob. Agents Chemother., May 1, 2005; 49(5): 1837 - 1843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Yucel, R. Lefering, M. Maegele, M. Max, R. Rossaint, A. Koch, R. Schwarz, M. Korenkov, J. Beuth, A. Bach, et al. Reduced colonization and infection with miconazole-rifampicin modified central venous catheters: a randomized controlled clinical trial J. Antimicrob. Chemother., December 1, 2004; 54(6): 1109 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Gollwitzer, K. Ibrahim, H. Meyer, W. Mittelmeier, R. Busch, and A. Stemberger Antibacterial poly(D,L-lactic acid) coating of medical implants using a biodegradable drug delivery technology J. Antimicrob. Chemother., March 1, 2003; 51(3): 585 - 591. [Abstract] [Full Text] [PDF]
|
|