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Journal of Antimicrobial Chemotherapy (2000) 46, 137-140
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

In vivo activity of the bis-triazole D0870 against drug-susceptible and drug-resistant strains of the protozoan parasite Trypanosoma cruzi

Judith Molinaa,b, Zigman Brenerb, Alvaro J. Romanhac and Julio A. Urbinad,*

a Departmento de Parasitología, Instituto de Zoología Tropical, Universidad Central de Venezuela, Caracas 1041, Venezuela; b Laboratorio de Doença de Chagas and c Laboratorio de Parasitologia Celular e Molecular, Centro de Pesquisas Rene Rachou, Fundaçao Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil; d Laboratorio de Química Biológica, Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Apartado 21827, Caracas 1020A, Venezuela

We report the in vivo activity of the bis-triazole derivative D0870 against a variety of strains of Trypanosoma cruzi, the causative agent of Chagas' disease, including nitroimidazole/nitrofuran-resistant strains. In both acute and chronic murine models of the disease, treatment with D0870 at <= 10 mg/kg on alternate days for a total of 20 doses provided 60–100% protection against death, regardless of the drug sensitivity of the infecting strain. In the acute model we obtained 70–100% parasitological cure in seven of the nine strains tested, including one intermediate and two highly drug-resistant strains. D0870 was able to cure 30–45% of animals chronically infected with various strains, including those harbouring the Colombiana strain, among which no cures were obtained with benznidazole. We also found that the anti-T. cruzi activity of D0870 is largely retained even if the hosts are immunosuppressed.

* Corresponding author. Tel: +58-2-5041479; Fax: +58-2-5041093; E-mail: jaurbina{at}cbb.ivic.ve


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