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Journal of Antimicrobial Chemotherapy (2000) 46, 109-113
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

In vitro potency of moxifloxacin, clinafloxacin and sitafloxacin against 248 genetically defined clinical isolates of Staphylococcus aureus

Franz-Josef Schmitza,b,*, Ad C. Fluitb, Dana Milatovicb, Jan Verhoefb, Hans-Peter Heinza and Sylvain Brisseb

a Institute for Medical Microbiology and Virology, Heinrich-Heine University Düsseldorf, Germany; b Eijkman-Winkler Institute for Medical Microbiology, Utrecht University, The Netherlands

The in vitro potency of three newer fluoroquinolones, moxifloxacin, clinafloxacin and sitafloxacin was tested against 248 genetically defined Staphylococcus aureus isolates, comprising 116 unrelated S. aureus, seven heterogeneous intermediate vancomycin-resistant S. aureus strains as well as 125 clonally related methicillin-resistant S. aureus. All strains were susceptible to clinafloxacin and sitafloxacin based on an investigational breakpoint of 1 mg/L and were less influenced by mutations within the grl and gyr gene loci. In one-quarter to one-third of the strains tested, reserpine decreased slightly the MICs of moxifloxacin, clinafloxacin and sitafloxacin. Compared with moxifloxacin, clinafloxacin and sitafloxacin showed a significantly increased anti-staphylococcal potency.

* Correspondence address. Institute for Medical Microbiology and Virology, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb. 22.21, 40225 Düsseldorf, Germany. Tel: +49-2132-72040; Fax: +49-2132-72040; E-mail: schmitfj{at}uni-duesseldorf.de


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