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Journal of Antimicrobial Chemotherapy (2000) 45, 871-875
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Presence of ROB-1 ß-lactamase correlates with cefaclor resistance among recent isolates of Haemophilus influenzae

James A. Karlowskya,b,c,*, Geetika Vermac, George G. Zhanela,b,c,d and Daryl J. Hobana,c

a Department of Medical Microbiology and b Faculty of Pharmacy, University of Manitoba; Departments of c Clinical Microbiology and d Medicine, Health Sciences Centre, Winnipeg, Manitoba, Canada

ß-Lactamase production in Canadian isolates of Haemophilus influenzae has remained relatively constant (25–35%) over the last decade despite increasing cefaclor resistance (MIC >= 32 mg/L). TEM (294/324, 90.7%) and ROB-1 (30/324, 9.3%) prevalence rates among 324 isolates of H. influenzae obtained from across Canada in 1997–1998 were similar (P > 0.05) to previously published reports. However, 66.7% (26/39) of cefaclor-resistant isolates were ROB-1-positive (P < 0.001) and the remaining four ROB-1-positive isolates were cefaclor-intermediate (MIC 16 mg/L). Susceptibilities to loracarbef (P < 0.001) and cefprozil were also reduced in the presence of ROB-1 while the activities of cefuroxime, cefotaxime, cefixime and imipenem were similar in both TEM- and ROB-1-positive solates.

* Correspondence address. Department of Clinical Microbiology, Health Sciences Centre, MS673, 820 Sherbrook Street, Winnipeg, Manitoba R3A 1R9, Canada. Tel: +1-204-787-4683; Fax: +1-204-787-4699; E-mail: jkarlowsky{at}hsc.mb.ca


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