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Journal of Antimicrobial Chemotherapy (2000) 45, 803-805
© 2000 The British Society for Antimicrobial Chemotherapy

Trans-epithelial intestinal elimination of moxifloxacin in rabbits

Albert Musafijaa, Jacob Ramonb, Yuri Shtelmana, Gila Yosepha, Bina Rubinovitza, Shlomo Segeva and Ethan Rubinsteina,*

a The Infectious Diseases Unit, and b Department of Urology, Chaim Sheba Medical Center, Tel Hashomer 52621, Tel Aviv University School of Medicine, Israel

The intestinal trans-epithelial elimination of moxifloxacin was measured in the jejunum, ileum, caecum and in the bile in a rabbit model. Over a 120 min period following a single parenteral administration of moxifloxacin 15 mg/kg, peak serum concentration was 3.1 (± 1.1) mg/L. The elimination constants were: 0.019 (± 0.017) µg/cm2/min, 0.011 (± 0.014) µg/cm2/min and 0.002 (± 0.002) µg/cm2/min in the jejunum, ileum and caecum, respectively. Per loop, over 120 min, the respective eliminated quantities were: 9.59 (± 9.37) µg, 8.26 (± 6.74) µg and 1.92 (± 1.86) µg. Biliary moxifloxacin concentrations varied between 1.30 and 5.16 mg/L and exceeded serum levels from 45 min onwards. Intestinal concentrations paralleled serum moxifloxacin levels. Altogether, approximately 4.5% of the moxifloxacin dose was eliminated trans-epithelially in the digestive tract over the 120 min experimental period.

* Corresponding author. Tel: +972-3-5303500; Fax: +972-3-5347081; E-mail: unit{at}netvision.net.il


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