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Journal of Antimicrobial Chemotherapy (2000) 45, 673-676
© 2000 The British Society for Antimicrobial Chemotherapy

Efficacy of voriconazole against invasive pulmonary aspergillosis in a guinea-pig model

P. H. Chandrasekar*, Jessica Cutright and Elias Manavathu

Division of Infectious Diseases, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA

We compared the efficacies of amphotericin B and voriconazole against invasive pulmonary aspergillosis in a guinea-pig model. A susceptible isolate of Aspergillus fumigatus was used to produce the infection. Voriconazole-treated animals had significantly better survival and decreased fungal burden in the lungs as compared with controls. Although no statistical difference was seen between the efficacies of voriconazole and amphotericin B, a trend favouring voriconazole was noted. Thus, voriconazole, with its cidal activity, may be an attractive alternative to potentially toxic amphotericin B in the treatment of invasive pulmonary aspergillosis.

* Corresponding author. Tel: +1-313-745-9649; Fax: +1-313-993-0302; E-mail: pchandrasekar{at}oncgate.roc.wayne.edu


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