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Journal of Antimicrobial Chemotherapy (2000) 45, 533-535
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Endothelial cell compatibility of trovafloxacin and levofloxacin for intravenous use

Christine Armbrustera,*, B. Robibarob, A. Griesmacherc and H. Vorbacha

a Second Medical Department/Pulmologisches Zentrum Vienna, Sanatoriumstrasse 2, A-1140 Vienna; b Department of Pulmonary Medicine, University Hospital of Vienna; c Institute of Laboratory Diagnostics, Kaiser Franz Josef Hospital, Vienna, Austria

Levofloxacin and trovafloxacin have excellent activity against a variety of Gram-positive and Gram-negative organisms resistant to the established agents. One local side-effect closely related to the use of parenteral fluoroquinolones is phlebitis. To evaluate the effect of trovafloxacin and levofloxacin on endothelial cell viability, intracellular levels of adenosine 5'-triphosphate (ATP), adenosine 5'-diphosphate (ADP), guanosine 5'-triphosphate (GTP) and guanosine 5'-diphosphate (GDP) levels were measured using high-performance liquid chromatography. Trovafloxacin at concentrations of 2 and 1 mg/mL reduced the intracellular ATP content from 12.5 ± 1.7 to 1.9 ± 0.3 nmol/106 cells and 9.3 ± 0.8 nmol/106 cells, respectively, within 60 min. In addition, ADP, GTP and GDP levels were extensively depleted. Levofloxacin at concentrations of 5 and 2.5 mg/mL led to a significant ATP decline from 12.5 ± 1.7 to 2.3 ± 0.2 nmol/106 cells and 10.3 ± 0.9 nmol/106 cells, respectively, within 60 min. These data indicate that infusions of high doses of trovafloxacin or levofloxacin are not compatible with maintenance of endothelial cell function. Commercial preparations have to be diluted and should be administered into large veins.

* Corresponding author. Tel/Fax: +43-1-877-58-20; E-mail: vorbach{at}austriaone.at


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