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Journal of Antimicrobial Chemotherapy (2000) 45, 525-528
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Activity of gemifloxacin, a new broad-spectrum quinolone, against 200 pneumococci by four different susceptibility testing methods

Lois M. Edniea, Michael R. Jacobsb and Peter C. Appelbauma,*

a Departments of Pathology (Clinical Microbiology), Hershey Medical Center, PO Box 850, Hershey, PA 17033; b Case Western Reserve University, Cleveland, OH 44106, USA

Agar and microdilution (in air), Etest (in air and CO2) and disc diffusion (in air and CO2) susceptibility testing methods were used to investigate the activity of gemifloxacin against 200 pneumococci. MIC50s were 0.016–0.03 mg/L and MIC90s 0.125–0.25 mg/L for all methods. With agar dilution as reference, 187/200 strains gave essential agreement with microdilution and 196 with Etest (air and CO2). Disc zones were a few millimetres narrower in CO2 than in air. With discs in CO2, all ciprofloxacin-susceptible strains yielded zone diameters 26 mm; values in air were 28 mm. Zones for ciprofloxacin-resistant strains in CO2 were mostly 21–26 mm; zones in air were a few millimetres wider, but mostly <31 mm.

* Corresponding author. Tel: +1-717-531-5113; Fax: +1-717-531-7953; E-mail: pappelbaum{at}psghs.edu


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