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Journal of Antimicrobial Chemotherapy (2000) 45, 375-377
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Anticryptosporidial activity of ranalexin, lasalocid and azithromycin alone and in combination in cell lines

A. Giacometti, O. Cirioni*, F. Barchiesi and G. Scalise

Institute of Infectious Diseases and Public Health, University of Ancona, Italy

The in vitro anticryptosporidial activities of ranalexin, lasalocid and azithromycin alone and in combination were investigated against four clinical isolates of Cryptosporidium parvum. Susceptibility was tested by inoculating the isolates on to cell monolayers and determining the parasite count after 48 h incubation at 37°C. The culture medium was supplemented with Dulbecco's modified Eagle's medium containing serial dilutions of the above-mentioned compounds. Ranalexin showed moderate anticryptosporidial activity: at a concentration of 64 mg/L it reduced parasite counts by 33.8%. Azithromycin at a concentration of 8 mg/L gave inhibition comparable to that observed with the highest concentration of ranalexin. Lasalocid showed the highest activity, with a 70.3% reduction in parasite counts at 2 mg/L. The combination of ranalexin 64 mg/L and lasalocid 2 mg/L completely suppressed parasite growth without harming the monolayer.

* Correspondence address. Clinica Malattie Infettive, c/o Azienda Ospedaliera Umberto I, Piazza Cappelli 1, I-60121 Ancona, Italy. Tel: +39-071-596-3467; Fax: +39-071-596-3468; E-mail: cmalinf{at}popcsi.unian.it


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