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Journal of Antimicrobial Chemotherapy (2000) 45, 371-373
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro

F. C. Oddsa,* and H. Vanden Bosscheb

a Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK; b Infectious Diseases Departments, Janssen Research Foundation, B-2340 Beerse, Belgium

Microbroth dilution tests in vitro showed the same IC50 values for itraconazole and hydroxy-itraconazole, within a mode ± one dilution range of experimental error, for 90% of 1481 isolates of pathogenic fungi, representing 48 genera. Some 10–15% of Candida glabrata and Trichophyton mentagrophytes isolates were more susceptible to itraconazole than hydroxy-itraconazole. Replicate tests with bioassay marker strains of Candida kefyr and Candida albicans showed no susceptibility variations outside the mode ± one dilution range. We conclude that few fungi differ substantially in their susceptibility to itraconazole and hydroxy-itraconazole.

* Corresponding author. Tel: +44-1224-273138; Fax +44-1224-273144; E-mail: f.odds{at}abdn.ac.uk


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