Journal of Antimicrobial Chemotherapy (2000) 45, 321-328
© 2000 The British Society for Antimicrobial Chemotherapy
A retrospective analysis of pharmacokinetic/pharmacodynamic indices as indicators of the clinical efficacy of ciprofloxacin
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Salamanca, Spain
A retrospective analysis of the relationship between estimated pharmacokinetic/pharmacodynamic indices and the reported efficacy of ciprofloxacin has been carried out using different correlation models. 
, Tss > MIC, 
and AUICss were calculated for each clinical case included in the study, from simulated plasma level curves corresponding to the dosage regimen administered. A univariate correlation analysis was performed considering efficacy (%) as the dependent variable and indices as the independent variables according to linear and non-linear pharmacokinetic–pharmacodynamic models (PK-PD models).The results prove that log-transformation of the independent variable improves the data fitting to linear model. The four estimated indices show a log-linear relationship with outcome, Tss > MIC and AUICss being the parameters best correlated with percentage efficacy. The Emax model with intrinsic response is an additional correlation strategy for Tss > MIC, leading to estimated values of Emax and E0 of 100.34 ± 25.09% and 24.40 ± 11.7%, respectively. The wide range of bacteria responsible for the infections considered, including Gram-positive pathogens such as staphylococci, might explain the good correlation between Tss > MIC and percentage efficacy found for ciprofloxacin in this study.
* Correspondence address. Departamento de Farmacia y Tecnología Farmaceútica, Facultad de Farmacia, Universidad de Salamanca, Avda del Campo Charro S. N., 37007 Salamanca, España. Tel: +34-923-294536; Fax: +34-923-294515; E-mail: asn{at}gugu.usal.es
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