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Journal of Antimicrobial Chemotherapy (2000) 45, 311-314
© 2000 The British Society for Antimicrobial Chemotherapy

Therapeutic effects of parenteral ß-lactam antibiotics on experimental otitis media caused by penicillin-resistant Streptococcus pneumoniae in guinea-pigs

Ritsuko Hori*, Harumi Araki, Minoru Yonezawa, Shinzaburo Minami and Yasuo Watanabe

Research Laboratories, Toyama Chemical Co. Ltd, 2-4-1 Shimookui, Toyama City, Toyama 930-8508, Japan

The therapeutic effects of parenteral ß-lactam antibiotics were evaluated in experimental acute otitis media caused by penicillin-resistant Streptococcus pneumoniae (PRSP) in guinea-pigs. Cefotaxime, ceftriaxone and piperacillin significantly reduced viable cell counts of PRSP in the middle ear at a dose of 50 mg/kg bd for 3 days (P < 0.01 compared with control). The therapeutic effects of cefotaxime, ceftriaxone and piperacillin were superior to those of cefotiam and ceftazidime. These therapeutic effects reflected both in vitro activity and pharmacokinetic properties of the drugs.

* Corresponding author. Tel: +81-76-431-8268; Fax: +81-76-431-8208.


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