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Journal of Antimicrobial Chemotherapy (2000) 45, 105-109
© 2000 The British Society for Antimicrobial Chemotherapy

Brief reports

Effect of conalbumin on the activity of Syn 2190, a 1,5 dihydroxy-4-pyridon monobactam inhibitor of AmpC ß-lactamases

Gioia S. Babini and David M. Livermore*

Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT, UK

Syn 2190, a 1,5 dihydroxy-4-pyridon monobactam inhibitor of AmpC enzymes, was tested against ß-lactamase-producing bacteria with piperacillin, piperacillin–tazobactam and ceftazidime as partner drugs. In the presence of conalbumin as an iron chelator, Syn 2190 potentiated these drugs against most AmpC producers, although Klebsiella spp. with plasmidic AmpC enzymes were an exception. Potentiation was much weaker without conalbumin, suggesting that Syn 2190 exploits a ferric uptake pathway, as do catecholic cephalosporins. Syn 2190 had little ability to potentiate partner drugs against strains with other ß-lactamase types but, with conalbumin, increased the activity of piperacillin–tazobactam against Escherichia coli transconjugants producing various class A or D enzymes.

* Corresponding author. Tel: + 44-181-200-4400 ext. 4223; Fax: + 44-181-200-7449; E-mail: DLivermore{at}phls.nhs.uk


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