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Journal of Antimicrobial Chemotherapy (1999) 44, Topic A, 1-9
© 1999 The British Society for Antimicrobial Chemotherapy

Antibiotic resistance in Gram-positive bacteria: epidemiological aspects

Wolfgang Witte*

Robert Koch Institute, Wernigerode Branch, Burgstrasse 37, D-38855 Wernigerode, Germany

The emergence and spread of antibiotic resistance in Gram-positive bacterial pathogens has become an increasing problem. There has been a dramatic increase in the prevalence of methicillin-resistant Staphylococcus aureus (MRSA), coagulase-negative staphylococci and enterococci. This is mainly due to the clonal dissemination of certain epidemic multiply- resistant strains, for example, those of MRSA and S. pneumoniae, as well as to the spread of resistance genes as exemplified by those causing glycopeptide resistance in enterococci.

* Tel: +49-3843-679-246; Fax: +49-3843-679-207; E-mail: wittew{at}rki.de


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