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Journal of Antimicrobial Chemotherapy (1999) 44, 705-708
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

Cytopathic effect inhibition assay for determining the in-vitro susceptibility of herpes simplex virus to antiviral agents

Manuel Cotareloa, Pilar Catalána,*, Carlos Sánchez-Carrilloa, Ana Menasalvasa, Emilia Cercenadoa, Antonio Tenoriob and Emilio Bouzaa

a Servicio de Microbiología Clínica y Enfermedades Infecciosas-VIH, Hospital General Universitario ‘Gregorio Marañón', Madrid 28007; b Centro Nacional de Microbiología, Virología e Inmunología Sanitarias, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain

We compare a rapid dilution method for the determination of antiviral susceptibility of herpes simplex virus (HSV) with the plaque reduction assay. A total of 84 HSV clinical isolates were studied by both methods to detect in-vitro resistance to acyclovir and foscarnet. The rapid method showed for the detection of HSV isolates resistant to acyclovir and foscarnet, a sensitivity of 96.8% and 100% and specificity of 100% and 100%, respectively. This method provides an easy and accurate screening procedure for the susceptibility testing of HSV to antiviral agents.

* Corresponding author. Tel:+34-1-586-84-53; Fax:+34-1-504-49-06; E-mail: micro{at}micro.hggm.es


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R. Stranska, A. M. van Loon, M. Polman, and R. Schuurman
Application of Real-Time PCR for Determination of Antiviral Drug Susceptibility of Herpes Simplex Virus
Antimicrob. Agents Chemother., September 1, 2002; 46(9): 2943 - 2947.
[Abstract] [Full Text] [PDF]


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