Journal of Antimicrobial Chemotherapy (1999) 44, 669-674
© 1999 The British Society for Antimicrobial Chemotherapy
Foreign body infection: a new rat model for prophylaxis and treatment
Infectious Diseases Research Group, Departments of Pathophysiology & Microbiology and Immunology, Catholic University of Leuven, Leuven, Belgium
A subcutaneous catheter model in the rat was developed that allowed the study of prevention and treatment strategies for foreign body infection. In contrast to earlier models, the foreign body was inoculated with a low inoculum of Staphylococcus epidermidis just before implantation, thus mimicking intraoperative contamination with skin flora. Reproducible infection of all catheters followed if no prophylaxis was given. However, foreign body infection could be prevented or treated with antibiotics such as teicoplanin, which was marginally effective, and rifampicin, which proved very effective.
* Correspondence address. Departement Pathofysiologie, Universitarie Ziekenhuizen en Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium. Tel:+32-16-344275; Fax:+32-16-344230; E-mail: eric.vanwijngaerden{at}uz.kuleuven.ac.be
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