Journal of Antimicrobial Chemotherapy (1999) 44, 621-627
© 1999 The British Society for Antimicrobial Chemotherapy
Activity of moxifloxacin against pathogens with decreased susceptibility to ciprofloxacin
a Department of Paediatrics b Centre for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178 c Childrens Hospital, San Diego, CA 92123, USA
A panel of 279 clinical isolates of Gram-positive cocci and Gram-negative bacilli with varying levels of resistance to ciprofloxacin were analysed for susceptibility to moxifloxacin, ciprofloxacin, ofloxacin and nalidixic acid. Moxifloxacin was eight- to 32-fold more potent than ciprofloxacin and ofloxacin against staphylococci and Streptococcus pneumoniae, and equivalent to eight-fold more potent against enterococci. Although ciprofloxacin was intrinsically more potent than the other quinolones against highly susceptible Gram-negative isolates, the percentages of Gram-negative isolates susceptible to 1 mg/L of moxifloxacin or ciprofloxacin, or 2 mg/L of ofloxacin were 78%, 80% and 76%, indicating in-vitro equivalence of the agents against a collection that included isolates with diminished quinolone susceptibility. Staphylococci were analysed according to their ciprofloxacin susceptibility status. As ciprofloxacin resistance increased to high levels, all quinolone MICs increased, but moxifloxacin and ofloxacin MICs increased less than ciprofloxacin MICs. In mutational studies moxifloxacin inhibited more mutants (69%) at a concentration of 1 mg/L than did ciprofloxacin (63%) at 1 mg/L or ofloxacin at 2 mg/L (31%). The study indicated that moxifloxacin is more potent than ciprofloxacin and ofloxacin against Gram-positive pathogens, may be comparable in activity against less quinolone-susceptible Gram-negative isolates (other than Pseudomonas aeruginosa), and is less affected than ciprofloxacin by mechanisms responsible for increasing quinolone resistance in staphylococci.
* Corresponding author. Tel +1-402-208-1881; Fax: +1-402-280-1225; E-mail: kstaac{at}creighton.edu
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Grayo, O. Join-Lambert, M. C. Desroches, and A. Le Monnier Comparison of the In Vitro Efficacies of Moxifloxacin and Amoxicillin against Listeria monocytogenes Antimicrob. Agents Chemother., May 1, 2008; 52(5): 1697 - 1702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Miller, P. M. Flynn, I. U. Scott, E. C. Alfonso, and H. W. Flynn Jr In vitro fluoroquinolone resistance in staphylococcal endophthalmitis isolates. Arch Ophthalmol, April 1, 2006; 124(4): 479 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Jacobs, S. Bajaksouzian, A. Windau, P. C. Appelbaum, M. V. Patel, S. V. Gupte, S. S. Bhagwat, N. J. De Souza, and H. F. Khorakiwala In Vitro Activity of the New Quinolone WCK 771 against Staphylococci Antimicrob. Agents Chemother., September 1, 2004; 48(9): 3338 - 3342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L D Liebowitz, M Slabbert, and A Huisamen National surveillance programme on susceptibility patterns of respiratory pathogens in South Africa: moxifloxacin compared with eight other antimicrobial agents J. Clin. Pathol., May 1, 2003; 56(5): 344 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Ince, X. Zhang, and D. C. Hooper Activity of and Resistance to Moxifloxacin in Staphylococcus aureus Antimicrob. Agents Chemother., April 1, 2003; 47(4): 1410 - 1415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N. Gilbert, S. J. Kohlhepp, K. A. Slama, G. Grunkemeier, G. Lewis, R. J. Dworkin, S. E. Slaughter, and J. E. Leggett Phenotypic Resistance of Staphylococcus aureus, Selected Enterobacteriaceae, and Pseudomonas aeruginosa after Single and Multiple In Vitro Exposures to Ciprofloxacin, Levofloxacin, and Trovafloxacin Antimicrob. Agents Chemother., March 1, 2001; 45(3): 883 - 892. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. S. Thomson Minimizing quinolone resistance: are the new agents more or less likely to cause resistance? J. Antimicrob. Chemother., June 1, 2000; 45(6): 719 - 723. [Full Text] [PDF]
|
|