Journal of Antimicrobial Chemotherapy (1999) 44, 607-610
© 1999 The British Society for Antimicrobial Chemotherapy
Characterization of expanded-spectrum cephalosporin resistance in E. coli isolates associated with bovine calf diarrhoeal disease
a Wyeth-Ayerst Research, 401 N. Middletown Rd, Pearl River, NY 10965 b Department of Veterinary and Microbiological Sciences, North Dakota State University, Fargo, ND, USA
Antibiotic resistance among Escherichia coli isolates from diarrhoeal disease in cattle was studied. Many of the isolates were multiply resistant to ß-lactams, including expanded-spectrum cephalosporins, aminoglycosides, sulphonamides, tetracycline and fluoroquinolones. In many of the isolates, IEF revealed a strong ß-lactamase band compatible with overexpression of the AmpC ß-lactamase, either alone or in addition to TEM-type enzymes. Several of the isolates also possessed genes encoding virulence factors associated with animal and human diarrhoeal diseases. These results suggest that the use of antibiotics in animals could lead to a reservoir of antibiotic-resistant bacteria that could potentially infect humans.
* Corresponding author. Tel: +1-914-732-4396; Fax:+1-914-732-5671; E-mail: bradfop{at}war.wyeth.com
Present address: Rutgers University, Piscataway, NJ, USA.
Present address: Food and Drug Administration, Center for
Veterinary
Medicine, Laurel, MD, USA.
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