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Journal of Antimicrobial Chemotherapy (1999) 44, 545-548
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

In-vitro activity of cefepime and seven other antimicrobial agents against 1518 non-fermentative Gram-negative bacilli collected from 48 Canadian health care facilities

J. M. Blondeaua,b,c,*, R. Laskowskia, S. Borsosa and The Canadian Afermenter Study Group

a Departments of Clinical Microbiology, St Paul's Hospital (Grey Nuns') and Saskatoon and District Health b Department of Pathology, Royal University Hospital c the Department of Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

Non-fermentative bacilli are primarily nosocomial pathogens, and are also often resistant in vitro to a broad range of antimicrobial agents. In this large Canadian study, we collected 1466 clinical, non-repeat isolates of Pseudomonas aeruginosa, 21 of Acinetobacterspp. and 31 Stenotrophomas maltophilia. MICs of eight antibiotics were determined by the NCCLS microdilution method in a central laboratory. Tobramycin was the most active agent against P. aeruginosa (94.5% susceptible); amikacin and imipenem were the most active against Acetinobacterspp. (100%) and ceftazidime was the most active against S. maltophilia (40.6%). Against each group of isolates, cefepime was active against 87, 86.4 and 15.6%, respectively. This in-vitro study showed that cefepime may be a useful additional agent in the treatment of infections caused by P. aeruginosaand Acinetobacterspp., but not when S. maltophilia is considered pathogenic.

* Correspondence address. Department of Clinical Microbiology, Royal Univeristy Hospital, 103 Hospital Avenue, Saskatoon, Saskatchewan, Canada S7N0W8. Tel: +1-306-655-6943; Fax: +1-306-655-6947; E-mail: blondeauj{at}sdh.sk.ca


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