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Journal of Antimicrobial Chemotherapy (1999) 44, 537-540
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

Contribution of the MexAB-OprM multidrug efflux system to the ß-lactam resistance of penicillin-binding protein and ß-lactamase-derepressed mutants of Pseudomonas aeruginosa

Ramakrishnan Srikumar, Eric Tsang and Keith Poole*

Department of Microbiology and Immunology, Queen's University, Kingston, Ontario K7L 3N6, Canada

Deletion of the mexAB-oprM multidrug efflux operon substantially compromised the ß-lactam resistance of ß-lactamase-derepressed mutants of Pseudomonas aeruginosa, although it had only a modest impact on resistance of a penicillin-binding protein mutant. This highlights the multifactorial nature of ß-lactam resistance in this organism. Moreover, the contribution of efflux to the net resistance seen in some ß-lactam-resistant mutants suggests that inhibition of MexAB-OprM-mediated drug efflux might be an effective approach to overcoming ß-lactam resistance attributed to efflux as well as to other mechanisms of ß-lactam resistance.

* Corresponding author. Tel: +1-613-533-6677; Fax: +1-613-533-6796; E-mail: poolek{at}post.queensu.ca


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