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Journal of Antimicrobial Chemotherapy (1999) 44, 287-290
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

Ceftriaxone versus vancomycin prophylaxis in cardiovascular surgery

Ulla-Stina Salminena,c,*, Timo U. T. Viljanen, Ville V. Valtonenb, Timo E. H. Ikonena, Antero E. Sahlmana and Ari L. J. Harjulaa,c

a The Deaconess Hospital in Helsinki b The Deaconess Hospital in Helsinki Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland c The Deaconess Hospital in Helsinki Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland

The efficacy of antibiotic prophylaxis in cardiac surgery was compared between 97 patients receiving a single 2 g dosage of ceftriaxone and 103 receiving 500 mg of vancomycin iv every 6 h for 48 h. The overall infection rate was 13.4% in the ceftriaxone and 10.7% in the vancomycin group. Four (4%) wound infections, including one mediastinitis, occurred in the ceftriaxone group and five (5%) in the vancomycin group, with no statistically significant difference. The findings of this study support the adequacy of a simple single dose of ceftriaxone prophylaxis in cardiac surgery, at least in hospitals with low incidence of vancomycin-resistant staphylococcal infections.

* Correspondence address: Helsinki University Central Hopsital, Department of Surgery, pl 260, Haartmaninkatu 4, FIN-00290 Helsinki, Finland. Tel: +358-9-4711; Fax: +358-9-471 5858; E-mail: ulla.s.salminen{at}netsonic.fi


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