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Journal of Antimicrobial Chemotherapy (1999) 44, 109-112
© 1999 The British Society for Antimicrobial Chemotherapy

Brief report

Effects of voriconazole on Candida glabrata in vitro

Anjni Koul, John Vitullo, Guadalupe Reyes and Mahmoud Ghannoum*

Center for Medical Mycology, University Hospitals of Cleveland and Case Western Reserve University, 11 100 Euclid Avenue, Cleveland, OH 44106-5028, USA

The effects of voriconazole on the growth, morphology and lipids of Candida glabratawere studied. MIC data showed that voriconazole was up to 32- to 64-fold more active than fluconazole in its ability to inhibit various C. glabrata strains. Voriconazole inhibited the growth of C. glabrata in a dose-dependent fashion. Electron microscope examination showed that voriconazole treatment affected the external and internal morphology of C. glabrata. Treatment of C. glabrata with voriconazole inhibited ergosterol synthesis and led to accumulation of methylated sterols. In contrast, no significant difference in phospholipid composition was observed between treated and untreated cells.

* Corresponding author. Tel: +1-216-844-8580; Fax: +1-216-844-1076.


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