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Journal of Antimicrobial Chemotherapy (1999) 43, Suppl. C, 67-70
© 1999 The British Society for Antimicrobial Chemotherapy

Levofloxacin: serum bactericidal activity against methicillin-resistant Staphylococcus aureus isolates

C. Muller-Serieys*, D. Decré, C. Benoit, C. Bigot, B. Maubert and C. Carbon

CHU Bichat-Claude Bernard, Paris, France

The aim of this study was to assess the serum bactericidal activity (SBA) of levofloxacin compared with that of ofloxacin against methicillin-resistant Staphylococcus aureus (MRSA) isolates. Serum from 10 healthy volunteers (seven females, three males) was collected after a single oral dose of either levofloxacin (500 mg) or ofloxacin (400 mg). Subjects were allocated randomly to treatment after at least a 1 week interval between antibiotic regimens. Three well-defined MRSA strains were tested, each susceptible to levofloxacin and ofloxacin, with different levels of resistance to methicillin (HBD 456, HBD 3 and HBD 2; class 1, 2 and 3 Tomasz heterogeneous resistance, respectively) together with a methicillin-susceptible (MSSA) reference strain (S. aureus ATCC 25923). SBA was tested in vitro by a microtitration method 15 min before dosing and at 1, 4, 8 and 12 h after drug absorption. Levofloxacin was significantly more bactericidal than ofloxacin against all strains of S. aureus tested (SBA >=1:2). An SBA was recorded for only a short period with ofloxacin, and thereafter only bacteriostatic activity remained. This study, therefore, confirms the superior activity of levofloxacin over that of ofloxacin against MSSA and MRSA.

* Correspondence address. Department of Bacteriology, Bichat-Claude Bernard University-Hospital, 46 Rue Henri-Huchard, 75877 Paris Cedex 18, France. Tel: +33-1-40-25-85-06; Fax: +33-1-40-25-85-81.


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