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Journal of Antimicrobial Chemotherapy (1999) 43, Suppl. C, 5-8
© 1999 The British Society for Antimicrobial Chemotherapy

A comparative study of the in-vitro activity of levofloxacin against Streptococcus pneumoniae

R. R. Reinerta,*, R. Lüttickena, M. Lemperlea and A. Bryskierb

a National Reference Centre for Streptococci, Institute of Medical Microbiology, University Hospital, Pauwelsstrasse 30, 52057 Aachen, Germany b Anti-infectives Research Group, Clinical Pharmacology, Hoechst Marion Roussel, Romainville Cedex, France

In this study, the in-vitroactivity of levofloxacin against Streptococcus pneumoniae was compared with the activities of a range of other antibiotics. In total, 320 penicillin-susceptible and 30 penicillin-intermediate clinical isolates of S. pneumoniae were collected in Germany between 1992 and 1994 from patients with bacteraemic pneumonia. MICs were determined using the agar dilution methodology recommended by the NCCLS and the results with levofloxacin compared with those with ofloxacin, D-ofloxacin, ciprofloxacin, amoxycillin, cefpodoxime, cefixime, cefuroxime, faropenem, erythromycin and tetracycline. Levofloxacin (MIC 50 1 mg/L) was approximately twice as active against the isolates as ofloxacin (MIC 50 2 mg/L). D-ofloxacin (MIC 90 32 mg/L) showed no activity, while ß-lactam antibiotics showed elevated MIC 90 values against penicillin-intermediate strains (amoxycillin, 1 mg/L; cefpodoxime, 2 mg/L; cefixime, 32 mg/L; cefuroxime, 8 mg/L) in comparison with the MIC 90 obtained with penicillin-susceptible strains (amoxycillin, 0.015 mg/L; cefpodoxime, 0.03 mg/L; cefixime, 0.5 mg/L; cefuroxime, 0.03 mg/L). Faropenem showed good activity against pneumococcal isolates (penicillin-susceptible strains, MIC 90 0.016 mg/L; penicillin-intermediate strains, MIC 90 0.25 mg/L). Erythromycin (MIC 90 8 mg/L) and tetracycline (MIC 90 64 mg/L) were also less active against penicillin-intermediate pneumococcal isolates. In conclusion, levofloxacin and faropenem may be useful in the treatment of pneumococcal infections caused by organisms with decreased susceptibility to penicillin.

* Corresponding author. Tel: +49-241-80-89-787; Fax: +49-241-88-88-483; E-mail: REINERT{at}aachen.de


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