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Journal of Antimicrobial Chemotherapy (1999) 43, Suppl. B, 25-29
© 1999 The British Society for Antimicrobial Chemotherapy

The in-vitro activity of moxifloxacin against Legionella species and the effects of medium on susceptibility test results

G. Ruckdeschel and A. Dalhoff*

Bayer AG, Pharma Research Centre, PO Box 101709, 42096 Wuppertal, Germany

The in-vitro activities of moxifloxacin, ciprofloxacin, erythromycin and rifampicin against 49 Legionella spp. isolates were determined by an agar dilution method with buffered charcoal yeast extract agar containing {alpha}-ketoglutarate. Because the inhibitory effects of charcoal in the test media were pronounced (92% for quinolones, 90.5% for rifampicin and 92.5% for erythromycin), the MICs were corrected for the charcoal-bound fraction of the antibiotics. The corrected geometric mean MICs were 0.018 mg/L for moxifloxacin, 0.02 mg/L for ciprofloxacin, 0.27 mg/L for erythromycin and 0.005 mg/L for rifampicin.

* Corresponding author. Tel: +49-202-368239; Fax: +49-202-364540; E-mail: AxelDalhoff. AD{at}bayer.ag.de


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