Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Klimberg, I. W.
Right arrow Articles by Echols, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Klimberg, I. W.
Right arrow Articles by Echols, R. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (1999) 43, Suppl. A, 77-84
© 1999 The British Society for Antimicrobial Chemotherapy

Single-dose oral ciprofloxacin compared with cefotaxime and placebo for prophylaxis during transurethral surgery

Ira W. Klimberga,*, G. H. Malekb, Clair E. Coxc, A. Lynn Pattersonc, Edward Whalend, Steven F. Kowalskyd and Roger M. Echolsd,{dagger}

a The Urology Center of Florida, Ocala, FL; b The Jackson Foundation for Medical Research and Education, Madison, WI; c University of Tennessee, Memphis, TN; d Bayer Corporation Pharmaceutical Division, West Haven, CT, USA

To determine the efficacy and safety of single-dose oral ciprofloxacin prophylaxis for the prevention of post-operative bacteriuria following transurethral resection of the prostate or bladder tumour, a prospective, randomized, double-blind, placebo-controlled trial was conducted. Five hundred and eighteen patients were randomized in a 2:2:1 ratio to receive ciprofloxacin 500 mg, cefotaxime 1 g or placebo 30- 90 min before surgery. Of the 368 efficacy-evaluable patients, five (3.3%) ciprofloxacin, seven (4.8%) cefotaxime and five (7.0%) placebo recipients had post- operative bacteriuria (>=10 4 cfu/mL) during post-operative days 2- 15. Five (3.4%) ciprofloxacin, five (3.4%) cefotaxime and one (2.4%) placebo recipients were considered clinical failures, of whom one, two and one patients, respectively, had concomitant bacteriuria. Drug-related adverse events were reported in six of 204 (3%) ciprofloxacin, 12 of 197 (6%) cefotaxime and one of 101 (1%) placebo patients. The observed rates of post-operative bacteriuria suggest that a single 500 mg dose of ciprofloxacin is suitable prophylaxis for transurethral surgery.

* Corresponding address. Urology Center of Florida, Inc., 3201 Southwest 34th Street, Ocala, FL 32674, USA. Tel:+1-352-237-8100; Fax: +1-352-237-5684.

{dagger} Current address. Bristol-Myers Squibb, Wallingford, CT, USA.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.