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Journal of Antimicrobial Chemotherapy (1999) 43, Suppl. A, 3-23
© 1999 The British Society for Antimicrobial Chemotherapy

In-vitro susceptibility of 1982 respiratory tract pathogens and 1921 urinary tract pathogens against 19 antimicrobial agents: a Canadian multicentre study

Joseph M. Blondeaua,*, Y. Yaschuka, M. Sutera, David Vaughanb and The Canadian Antimicrobial Study Group

a Division of Clinical Microbiology, Saskatoon District Health and St Paul's Hospital (Grey Nuns) and the University of Saskatchewan, Saskatoon, Saskatchewan b Anti-Infective Division, Bayer Health Care, Toronto, Ontario, Canada

A total of 3903 pathogens from 48 Canadian medical centres were tested against 19 antimicrobial agents. Five agents showed activity against >=90%; cefoperazone, 91%; ticarcillin/clavulanate, 92%; ceftazidime and imipenem, 93% each). Nine agents had >=90% activity against Enterobacteriaceae from respiratory tract infection (cefotaxime and ticarcillin/clavulanate, 90% each; aztreonam, ceftizoxime and ceftriaxone, 91% each; ceftazidime, 93%; ciprofloxacin, 97%; imipenem and netilmicin, 98% each). Similarly, five agents had activity against >=90% of all 1921 urinary tract pathogens tested (ciprofloxacin and ticarcillin/clavulanate, 90% each; cefoperazone and netilmicin, 91% each; imipenem, 99%). Nine agents had >=95% activity against Enterobacteriaceae from urinary tract infection (ciprofloxacin, 95%; cefotetan, 97%; aztreonam, cefotaxime, ceftazidime, ceftizoxime, ceftriaxone and netilmicin, 98% each; imipenem, 99%). Seventeen agents had activity against >=95% of Staphylococcus aureus strains. Susceptibility of Pseudomonas aeruginosa isolates ranged from 2% to 91%.

* Corresponding address: Department of Clinical Microbiology, Royal University Hospital, 103 Hospital Drive, Saskatoon, Saskatchewan, Canada S7N 0W8. Tel:+1-306-655-6943; Fax: +1-06-655-6947; E-mail: blondeauj{at}sdh.sk.ca


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